Dr. Squire J. Booker

Squire J. Booker is a Richard Perry University Professor of Chemistry and Biochemistry and Biophysics at the University of Pennsylvania. He is also an Investigator of the Howard Hughes Medical Institute and an Emeritus Professor of Chemistry and Biochemistry and Molecular Biology at The Pennsylvania State University. Booker received a BA degree with a concentration in Chemistry from Austin College (Sherman, Texas) in 1987. He earned his Ph.D. degree from the Massachusetts Institute of Technology under Professor JoAnne Stubbe (1994) and was supported by NSF–NATO and NIH Fellowships for postdoctoral studies in the laboratories of Dr. Daniel Mansuy (Université René Descartes, Paris, France) and Professor Perry Frey (Institute for Enzyme Research, University of Wisconsin–Madison), respectively. In 1999, he moved to The Pennsylvania State University as an independent investigator, where he spent twenty-six years before his recent move to the University of Pennsylvania in June 2025. Booker’s research concerns novel mechanisms and pathways for the biosynthesis of various natural products and cellular metabolites, focusing on enzymes that use S-adenosylmethionine and iron-sulfur clusters to catalyze reactions via radical mechanisms. Currently, he is an Associate Editor for the ACS journal Biochemistry and Deputy Editor for ACS Bio & Med Chem Au.